An efficient procedure for the synthesis of benzoxazole and. The parent benzoxazole scaffold has a planar geometry and is found to be a constituent of several naturally occurring molecules. Synthesis of benzoxazoles, benzimidazoles, and benzothiazoles. Promoted solvent free synthesis of benzoxazoles, benzimidazoles, and benzothiazole derivatives article pdf available september 2012 with 156 reads how we measure reads. A new series of benzoxazole analogues was synthesized and. The mild reaction conditions, and particularly insensitivity to air and water, further enhance the synthetic potential in pharmaceutical synthesis. Synthesis and characterization of oxazolopyridine and. Synthesis, molecular docking and antimicrobial evaluation. The synthesis of benzoxazole on a solid support is demonstrated by the synthesis of.
Synthesis of benzoxazole and benzimidazole derivatives via. Design, synthesis and biological evaluation of 2thio. Catalytic amounts of tetrabutylammoniumiodide tbai, aqueous solutions of h 2 o 2 or tbhp as cooxidant enabled an efficient transitionmetal free amination of benzoxazoles under mild reaction conditions, to yield highly desirable 2aminobenzoxazoles in good yields. Facile and efficient synthesis of benzoxazole derivatives using novel. Heterogeneous catalyst under a solventfree condition. A ballmilling strategy for the synthesis of benzothiazole. Lawessons reagent is an efficient promoter in the solventfree microwave assisted synthesis of 2substituted benzoxazoles and benzothiazoles from carboxylic. An efficient protocol has been developed for the preparation of a library of benzoxazole, benzimidazole, and benzothiazole derivatives from reactions of acyl. Phosphorus, sulfur, and silicon and the related elements to view the free supplemental file. All authors read and approved the final manuscript.
Efficient onepot synthesis of benzoxazole derivatives. Synthesis of 2aryl benzoxazoles from aldoximes medcrave. A small library of compounds with oxazole and thiazole scaffolds and structural diversity in both positions 2 and 5 has been synthesized. Synthesis of benzoxazole2ones, benzothiazole2ones and. Lawessons reagent is an efficient promoter in the solventfree microwaveassisted synthesis of 2substituted benzoxazoles and benzothiazoles from carboxylic. The designing, synthesis, antimicrobial activity and spectral analysis of the prepared benzoxazole derivatives was done by the authors bn, sk and st. An update on the synthesis of benzoxazoles semantic. This is an attractive alternative method for the synthesis of oxazole derivatives. A metal free and catalytic method for the synthesis of 2substituted benzoxazoles and benzothiazoles from nprotected amino acids and carboxylic acids is described.
An update on the synthesis of benzoxazoles request pdf. Various 2substituted benzoxazoles were obtained through these reactions. Pdf benzoxazole and benzothiazole synthesis benzoxazole. The anticancer evaluation of synthesized compounds was carried out by the authors kr, saas, sml and vm. In continuation of the work on benzoxazoles present work deals with the synthesis,characterization and evaluation of 2aminon substituted alkyl benzoxazole 5 carboxamides for anti. Benzoxazole is an important class of heterocycle having a bicyclic structure in which an aryl ring is fused with the d site of an oxazole moiety. Abstract a novel and efficient synthesis of benzoxazole and benzimidazole derivatives via a ligand. Different substituents such as methyl, chloro, bromo, nitro, and methoxy on 2aminophenol are tolerated under the optimized reaction conditions. Synthesis and pharmacological screening of some noval. The synthesis and properties of benzoxazole fluorescent.